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Deletion of Cell Division Cycle 2-Like 1 Gene Locus on 1p36 in Non-Hodgkin Lymphoma
Ist Teil von
Cancer genetics and cytogenetics, 1999-01, Vol.108 (2), p.120-126
Ort / Verlag
New York, NY: Elsevier Inc
Erscheinungsjahr
1999
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
Our laboratories have documented a significantly high occurrence of chromosome 1p36 rearrangements in non-Hodgkin lymphoma (NHL). The cell division cycle 2-like 1(
CDC2L1) (also known as
TP58 or
PITSLRE) gene, a protein kinase implicated in apoptotic signaling, is located at the very distal region of chromosome 1p36 and is likely to be disrupted by structural rearrangements involving 1p36. To determine the molecular consequences of the recurrent involvement of the 1p36 region, we examined metaphases containing 1p36 abnormalities from 31 specimens derived from 26 patients for the possible deletion of
CDC2L1 by fluorescence in situ hybridization (FISH) using the
TP58
clk-1 DNA probe. Twenty-three cases exhibited the loss of
CDC2L1 from the abnormal chromosome 1. In 2 of 26 cases, the gene locus was translocated to the partner chromosome, and in four specimens, all derived from one case,
CDC2L1 was not deleted. This pilot investigation suggests that 1p36 rearrangements, and consequently the loss of the
CDC2L1 gene locus, is important in NHL. This work also opens avenues for further molecular studies and prognostic correlations.