Details

Autor(en) / Beteiligte

• Abu-Elyazeed, Remon
• Wierzba, Thomas F.
• Mourad, Ali S.
• Peruski, Leonard F.
• Kay, Bradford A.
• Rao, Malla
• Churilla, Albert M.
• Bourgeois, A. Louis
• Mortagy, Ahmed K.
• Kamal, Salwa M.
• Savarino, Stephen J.
• Campbell, James R.
• Murphy, James R.
• Naficy, Abdollah
• Clemens, John D.

Titel

Epidemiology of Enterotoxigenic Escherichia coli Diarrhea in a Pediatric Cohort in a Periurban Area of Lower Egypt

Ist Teil von

• The Journal of infectious diseases, 1999-02, Vol.179 (2), p.382-389

Ort / Verlag

Chicago, IL: University Chicago Press

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Enterotoxigenic Escherichia coli (ETEC) are diverse pathogens that express heat-labile (LT) and/or heat-stable (ST) enterotoxins, yet little is known about whether epidemiologic patterns of pediatric ETEC diarrhea vary by the expressed ETEC toxin phenotype. In total, 242 Egyptian children aged < 3 years were prospectively followed in 1993–1995. ETEC episodes were detected during twice-weekly home visits, and asymptomatic ETEC excretion was identified from monthly cross-sectional surveys. ETEC episodes were 0.6 per child-year. ST-only ETEC was 2.6 times (P < .001) more common in warmer than cooler months, while LT-only ETEC showed no seasonal variation. Ownership of a household sanitary latrine, but not breast-feeding, was associated with a lower risk of both enterotoxin phenotypes. Coexpression of a colonization factor by LT- or ST-only ETEC strengthened the association with diarrhea. These findings indicate that the epidemiologic patterns of LT-only and ST-only ETEC are not identical and that disease interventions should include improved household sanitation.