Details

Autor(en) / Beteiligte

• Fuchs, Charles S
• Giovannucci, Edward L
• Colditz, Graham A
• Hunter, David J
• Stampfer, Meir J
• Rosner, Bernard
• Speizer, Frank E
• Willett, Walter C

Titel

Dietary Fiber and the Risk of Colorectal Cancer and Adenoma in Women

Ist Teil von

• The New England journal of medicine, 1999-01, Vol.340 (3), p.169-176

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek (Open access)

Beschreibungen/Notizen

• The rarity of colorectal cancer in Africa suggested to Burkitt several decades ago that the high-fiber diet of Africans was protective against colorectal cancer. 1 Since then, dietary fiber has been postulated to prevent colorectal cancer by diluting or adsorbing fecal carcinogens, reducing colonic transit time, altering bile acid metabolism, reducing colonic pH, or increasing the production of short-chain fatty acids. 2 Despite the intuitive appeal of Burkitt's hypothesis, epidemiologic studies of a possible link between dietary fiber and colorectal cancer have been inconclusive. 3 The limited data on other dietary factors included in most studies did not permit a clear distinction to . . .