UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 21 von 51
Datensatz exportieren als...
BibTeX
Self-assembling peptide nanofibers and skeletal myoblast transplantation in infarcted myocardium
Journal of biomedical materials research. Part B, Applied biomaterials, 2008-10, Vol.87B (1), p.222-228
Dubois, Gilbert
Segers, Vincent F. M.
Bellamy, Valérie
Sabbah, Laurent
Peyrard, Séverine
Bruneval, Patrick
Hagège, Albert A.
Lee, Richard T.
Menasché, Philippe
2008
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Dubois, Gilbert
Segers, Vincent F. M.
Bellamy, Valérie
Sabbah, Laurent
Peyrard, Séverine
Bruneval, Patrick
Hagège, Albert A.
Lee, Richard T.
Menasché, Philippe
Titel
Self-assembling peptide nanofibers and skeletal myoblast transplantation in infarcted myocardium
Ist Teil von
Journal of biomedical materials research. Part B, Applied biomaterials, 2008-10, Vol.87B (1), p.222-228
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Cell transplantation is currently limited by poor graft retention and survival in the postinfarction scar. Because this issue could potentially be addressed by embedding cells in bioinjectable scaffolds and boosting cell survival pathways, we induced a myocardial infarction in 72 rats to assess the effects of different self‐assembling peptides with or without platelet‐derived growth factor (PDGF‐BB) on survival of transplanted skeletal myoblasts. Two weeks after coronary artery ligation, rats were randomized to receive in‐scar injections of culture medium (controls, n = 11), self‐assembling peptide (RAD16‐I) nanofibers (NF, n = 9), skeletal myoblasts (n = 12), or skeletal myoblasts in combination with NF (n = 8). In separate experiments with different self‐assembling peptides (RAD16‐II), rats received in‐scar injections of culture medium (controls, n = 6), skeletal myoblasts (n = 10), PDGF‐loaded peptides (n = 7), or skeletal myoblasts (5 × 106) in combination with PDGF‐loaded peptides (n = 9). After 1 month, left ventricular function, as assessed by echocardiography, was not improved in either of the experimental groups compared with controls. This correlated with the failure of RAD16‐I peptides or PDGF‐loaded RAD16‐II peptides to improve myoblast survival despite a greater angiogenesis. In vitro experiments confirmed that the number of myoblasts decreased over time when seeded on nanofiber gels. These data suggest that the optimal use of biomaterial scaffolds for survival of transplanted cells will require specific tailoring of the biomaterial to the cell type. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Sprache
Englisch
Identifikatoren
ISSN: 1552-4973
eISSN: 1552-4981
DOI: 10.1002/jbm.b.31099
Titel-ID: cdi_proquest_miscellaneous_69540234
Format
–
Schlagworte
allogeneic cell
,
Animals
,
cardiac tissue engineering
,
cell proliferation
,
Cell Transplantation
,
muscle
,
Myoblasts, Skeletal - transplantation
,
Myocardial Infarction - therapy
,
Nanostructures - therapeutic use
,
peptide
,
Peptides - therapeutic use
,
Platelet-Derived Growth Factor - therapeutic use
,
Proto-Oncogene Proteins c-sis
,
Rats
,
scaffold
,
Treatment Failure
,
Treatment Outcome
,
Ventricular Function, Left
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX