Details

Autor(en) / Beteiligte

• Caralt, Mireia
• Bilbao, Itxarone
• Cortés, Javier
• Escartín, Alfredo
• Lázaro, José Luís
• Dopazo, Cristina
• Olsina, Jorge Juan
• Balsells, Joaquim
• Charco, Ramon

Titel

Hepatic Resection for Liver Metastases as Part of the “Oncosurgical” Treatment of Metastatic Breast Cancer

Ist Teil von

• Annals of surgical oncology, 2008-10, Vol.15 (10), p.2804-2810

Ort / Verlag

New York: Springer-Verlag

Erscheinungsjahr

2008

Quelle

SpringerLink

Beschreibungen/Notizen

• Background Metastatic breast cancer is considered an incurable disease despite new therapies. Recent studies suggest that liver resection associated with systemic treatment may improve patient survival. Patients and methods Patient selection criteria were: good performance status, the feasibility of a complete and safe surgical procedure, and absence of uncontrolled extrahepatic metastases. The information was collected prospectively and analyzed retrospectively from our database. Results Between 1988 and 2006, 13 liver resections were performed in 12 patients owing to metastatic breast cancer. Two patients had synchronous metastases and ten metachronous metastases. One patient had extrahepatic bone metastases at the time of liver resection. Median follow-up was 35.9 months (range 12–113.4 months). Median age at liver resection was 58.4 years (range 36–76 years). Median hospital stay was 8 days (range 6–24 days); two patients had biliary leak but none died during the postoperative course. Seven patients (58.3%) developed hepatic recurrence. One-, 3-, and 5-year actuarial patient survival was 100%, 79%, and 33%, respectively. Patients who developed liver metastases within the first 24 months and after the first 24 months post-breast surgery had 1-, 3-, and 5-year actuarial patient survival of 100%, 0%, and 0% and 100%, 83%, and 60%, respectively ( P  < 0.025). Conclusion Liver resection for breast cancer liver metastases has an important role in the oncosurgical treatment of metastatic breast cancer with excellent 3-year survival.