Details

Autor(en) / Beteiligte

• Albu, Gergely
• Peták, Ferenc
• Fontao, Fabienne
• Biton, Catherine
• Pache, Jean-Claude
• Habre, Walid

Titel

Mechanisms of airway hyper-responsiveness after coronary ischemia

Ist Teil von

• Respiratory physiology & neurobiology, 2008-08, Vol.162 (3), p.176-183

Ort / Verlag

Amsterdarm: Elsevier B.V

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract We explored the consequences of myocardial ischemia (MI) on the lung responsiveness and identified the pathophysiological mechanisms involved. Airway resistance ( Raw ) was identified from the respiratory system input impedance ( Zrs ) in rats. Zrs was determined under baseline conditions, and following iv boluses of 20 and 30 μg/kg serotonin. MI was then induced in the animals in Group I by ligating the left-interventricular coronary artery, while rats in Group C underwent sham surgery. Four weeks later, baseline Zrs and its changes following serotonin administration were reassessed. Lung morphological changes were assessed by histology, and alpha smooth muscle actin cells (α-SMA) were identified. MI induced no changes in baseline Raw but led to bronchial hyper-reactivity (BHR) with 2.7 ± 0.5-times ( p < 0.05) greater responses in Raw to 30 μg/kg serotonin. Perivascular edema and α-SMA cell proliferation were observed after MI. The development of BHR following MI is a consequence of the expression of α-SMA, while the geometrical alterations caused by the pulmonary vascular engorgement have smaller impact.