Details

Autor(en) / Beteiligte

• Cesaro, Simone
• Boaro, Maria Paola
• Pillon, Marta
• Calore, Elisabetta
• Cermakova, Ivete
• Perruccio, Katia
• Mengoli, Carlo
• Messina, Chiara

Titel

Immune reconstitution complicated by CMV retinitis in a pediatric patient who underwent haploidentical CD34+-selected hematopoietic stem cell transplant for acute lymphoblastic leukemia

Ist Teil von

• International journal of hematology, 2008-09, Vol.88 (2), p.145-148

Ort / Verlag

Tokyo: Springer Japan

Erscheinungsjahr

2008

Link zum Volltext

Quelle

SpringerLink

Beschreibungen/Notizen

• We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of circulating CMV-specific clones. Antiviral treatment with foscarnet and ganciclovir was successful but prolonged treatment was required to prevent relapses. We hypothesize that this complication was more related to an immune reconstitution process than to an immune-deficient state post-grafting. We conclude that CMV retinitis is a late complication of HSCT that can occur despite satisfactory immune reconstitution. Usually, it is responsive to antiviral therapy. Dilated fundoscopic examination is essential both for examining patients with reduced visual acuity and for screening asymptomatic patients.