Current opinion in immunology, 2008-10, Vol.20 (5), p.538-544
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Pentraxins, humoral innate immunity and tissue injury
- Ist Teil von
- Current opinion in immunology, 2008-10, Vol.20 (5), p.538-544
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2008
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Tissue damage elicits an inflammatory response, which comprises the rapid synthesis of acute phase molecules. The early local response shapes the resolution of inflammation. Pentraxins are evolutionary conserved soluble pattern recognition receptors, produced in the liver (e.g. C-reactive protein) or at sites of inflammation (the long pentraxin PTX3). Pentraxins behave as flexible adaptors of innate cell functions, complement activation and clearance of cell and matrix debris, regulating tissue hyperplasia and scarring and limiting the risk of autoimmunity associated to unscheduled cell death in vivo.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0952-7915eISSN: 1879-0372DOI: 10.1016/j.coi.2008.05.004Titel-ID: cdi_proquest_miscellaneous_69517897
- Format
- –
- Schlagworte
- Acute-Phase Proteins - immunology, Acute-Phase Proteins - metabolism, Allergy and Immunology, Animals, Antibody Formation - immunology, Apoptosis - immunology, C-Reactive Protein - immunology, C-Reactive Protein - metabolism, Humans, Inflammation - immunology, Inflammation - metabolism, Mice, Serum Amyloid P-Component - immunology, Serum Amyloid P-Component - metabolism, Wounds and Injuries - immunology, Wounds and Injuries - metabolism