Details

Autor(en) / Beteiligte

• van der Pouw Kraan, T C
• van Veen, A
• Boeije, L C
• van Tuyl, S A
• de Groot, E R
• Stapel, S O
• Bakker, A
• Verweij, C L
• Aarden, L A
• van der Zee, J S

Titel

An IL-13 promoter polymorphism associated with increased risk of allergic asthma

Ist Teil von

• Genes and immunity, 1999-09, Vol.1 (1), p.61-65

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

1999

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position -1055. The IL-13 -1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma.