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Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2008-09, Vol.147B (6), p.990-995
Roffman, Joshua L.
Weiss, Anthony P.
Deckersbach, Thilo
Freudenreich, Oliver
Henderson, David C.
Wong, Donna H.
Halsted, Charles H.
Goff, Donald C.
2008
Details
Autor(en) / Beteiligte
Roffman, Joshua L.
Weiss, Anthony P.
Deckersbach, Thilo
Freudenreich, Oliver
Henderson, David C.
Wong, Donna H.
Halsted, Charles H.
Goff, Donald C.
Titel
Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia
Ist Teil von
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2008-09, Vol.147B (6), p.990-995
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Schizophrenia is characterized by heritable deficits in executive function. Two common, functional polymorphisms, catechol‐O‐methyltransferase (COMT) Val108/158Met and methylenetetrahydrofolate reductase (MTHFR) C677T, have separately been associated with executive function performance in schizophrenia. Given the closely related biochemistry of MTHFR and COMT, it is plausible that the T and Val alleles act synergistically to impair executive function. This investigation of 185 outpatients with schizophrenia examined the interactive effects of these two polymorphisms on Wisconsin Card Sorting Task (WCST) performance. Two WCST measures consistently associated with schizophrenia, perseverative errors and inability to generate categories, were contrasted among compound COMT‐MTHFR genotype groups. Individuals homozygous for the COMT Val allele who also carried at least one copy of the MTHFR T allele exhibited a significantly higher percentage of perseverative errors than patients in the other genotype groups. While the T allele also exerted a negative effect on category generation, COMT genotype did not contribute to category performance. It is plausible that cumulative effects of the MTHFR T and COMT Val alleles on intracellular methylation profiles and prefrontal dopamine transmission underlie their interactive effect on perseverative errors. © 2008 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4841
eISSN: 1552-485X
DOI: 10.1002/ajmg.b.30684
Titel-ID: cdi_proquest_miscellaneous_69481658
Format
–
Schlagworte
Adult
,
Adult and adolescent clinical studies
,
Amino Acid Substitution - physiology
,
Biological and medical sciences
,
Catechol O-Methyltransferase - genetics
,
Cognition - physiology
,
COMT
,
DNA Methylation
,
Dopamine - metabolism
,
Epigenesis, Genetic - physiology
,
executive function
,
Female
,
Genotype
,
Humans
,
Male
,
Medical genetics
,
Medical sciences
,
Methionine - genetics
,
methylation
,
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
,
Middle Aged
,
Models, Biological
,
MTHFR
,
Polymorphism, Single Nucleotide - physiology
,
Psychology. Psychoanalysis. Psychiatry
,
Psychopathology. Psychiatry
,
Psychoses
,
Schizophrenia
,
Schizophrenia - genetics
,
Schizophrenia - physiopathology
,
Schizophrenic Psychology
,
Synaptic Transmission - genetics
,
Valine - genetics
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