Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4838-4843
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase
- Ist Teil von
- Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4838-4843
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented. A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894X, 0968-0896eISSN: 1464-3405, 1464-3391DOI: 10.1016/j.bmcl.2008.07.081Titel-ID: cdi_proquest_miscellaneous_69477373
- Format
- –
- Schlagworte
- Amidohydrolases - antagonists & inhibitors, Amidohydrolases - deficiency, Amidohydrolases - genetics, Anandamide, Animals, Biological and medical sciences, CB1, CB2, FAAH, Fatty acid amide hydrolase, Lipid, Medical sciences, Mice, Mice, Knockout, Miscellaneous, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Pharmacology. Drug treatments, Piperazine, Piperazines - chemistry, Piperazines - pharmacokinetics, Piperazines - pharmacology, Thiadiazole, Thiadiazoles - chemistry, Thiadiazoles - pharmacokinetics, Thiadiazoles - pharmacology, Time dependant inhibition, Urea, Urea - analogs & derivatives, Urea - chemistry, Urea - pharmacokinetics, Urea - pharmacology