Details

Autor(en) / Beteiligte

• Gissel, Tina
• Rejnmark, Lars
• Mosekilde, Leif
• Vestergaard, Peter

Titel

Intake of vitamin D and risk of breast cancer—A meta-analysis

Ist Teil von

• The Journal of steroid biochemistry and molecular biology, 2008-09, Vol.111 (3), p.195-199

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Vitamin D insufficiency has been shown to be associated with a number of conditions including diabetes, multiple sclerosis and the overall risk of cancer. We aimed at studying the association between vitamin D intake and risk of breast cancer in a meta-analysis. We searched Pubmed, Embase, and Web of Science using the MESH terms “vitamin D” and “breast cancer”. A total of 1731 studies were identified, but only 6 studies contained original data on the association between intake of vitamin D and risk of breast cancer. Overall there was no association between amount of vitamin D and risk of breast cancer (RR = 0.98, 95% CI: 0.93–1.03, test for heterogeneity p < 0.01). However, most studies reported on very low intakes of vitamin D (typically in the range 100–400 IU/day). Restricting the analyses to intakes ≥400 IU/day yielded a more homogenous result with a trend towards less breast cancer with ≥400 IU/day vs. the lowest intake (typically <50–150 IU/day), RR = 0.92, 95% CI: 0.87–0.97, p for heterogeneity 0.14. In conclusion there may be a trend towards fewer cases of breast cancer with higher intakes of vitamin D (≥400 IU/day). However, more research is needed, preferably in the form of randomized-controlled trials.