Bioscience, biotechnology, and biochemistry, 2008-08, Vol.72 (8), p.2214-2218
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Inhibition of thioredoxin reductase by curcumin analogs
- Ist Teil von
- Bioscience, biotechnology, and biochemistry, 2008-08, Vol.72 (8), p.2214-2218
- Ort / Verlag
- Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Curcumin analogs were first investigated for their inhibitory effects on thioredoxin reductase (TrxR). Most of them were more potent TrxR inhibitors than natural curcumin. The structure-activity relationship was summarized, and the curcumin analog was found to inhibit TrxR irreversibly in a time-dependent manner. The action was caused by covalent modification of the redox-active residues Cyssup(497) and Secsup(498) in TrxR.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0916-8451eISSN: 1347-6947DOI: 10.1271/bbb.80229Titel-ID: cdi_proquest_miscellaneous_69456619
- Format
- –
- Schlagworte
- ANTIOXIDANTES, ANTIOXIDANTS, ANTIOXYDANT, ARN, Biological and medical sciences, CHEMICAL SYNTHESIS, CURCUMA (EPICE), CURCUMA (ESPECIA), CURCUMA LONGA, Curcumin - analogs & derivatives, Curcumin - pharmacology, curcumin analogs, ENZIMAS, ENZYME, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, ENZYMES, Fundamental and applied biological sciences. Psychology, Molecular Structure, OXIDOREDUCTIONS, OXIRREDUCION, OXYDOREDUCTION, RNA, SINTESIS QUIMICA, SYNTHESE CHIMIQUE, thioredoxin, thioredoxin reductase inhibitors, Thioredoxin-Disulfide Reductase - antagonists & inhibitors, Thioredoxin-Disulfide Reductase - metabolism, TURMERIC