Immunity (Cambridge, Mass.), 2008-08, Vol.29 (2), p.178-181
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Structural Mechanism of RNA Recognition by the RIG-I-like Receptors
- Ist Teil von
- Immunity (Cambridge, Mass.), 2008-08, Vol.29 (2), p.178-181
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Cytoplasmic nonself RNA, such as that generated by invading viruses, is recognized by a family of sensory molecules termed RIG-I-like Receptors (RLRs). Here, we discuss the mechanism of the RLRs' sensing of nonself RNA. Our findings define three functional domains of RLRs and provide insights into how RLRs function as a molecular switch through interactions with virus-specific RNA ligands.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1074-7613eISSN: 1097-4180DOI: 10.1016/j.immuni.2008.07.009Titel-ID: cdi_proquest_miscellaneous_69429356
- Format
- –
- Schlagworte
- Animals, CARD Signaling Adaptor Proteins - immunology, CARD Signaling Adaptor Proteins - metabolism, Cell culture, DEAD Box Protein 58, DEAD-box RNA Helicases - chemistry, DEAD-box RNA Helicases - genetics, DEAD-box RNA Helicases - immunology, DEAD-box RNA Helicases - metabolism, Influenza, Ligands, Mice, NMR, Nuclear magnetic resonance, Protein Structure, Tertiary, Proteins, RNA, Double-Stranded - immunology, RNA, Double-Stranded - metabolism, RNA, Viral - immunology, RNA, Viral - metabolism, Viral infections, Viruses