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Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target
Genes chromosomes & cancer, 2008-10, Vol.47 (10), p.873-883
Fejzo, Marlena S.
Dering, Judy
Ginther, Chuck
Anderson, Lee
Ramos, Lilian
Walsh, Christine
Karlan, Beth
Slamon, Dennis J.
2008
Details
Autor(en) / Beteiligte
Fejzo, Marlena S.
Dering, Judy
Ginther, Chuck
Anderson, Lee
Ramos, Lilian
Walsh, Christine
Karlan, Beth
Slamon, Dennis J.
Titel
Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target
Ist Teil von
Genes chromosomes & cancer, 2008-10, Vol.47 (10), p.873-883
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Approximately 25,000 ovarian cancers are diagnosed in the US annually, and 75% of cases are in the advanced stage when they are largely incurable. There is a critical need for improved early detection tools and development of novel treatments. Because chromosome band 20q13 is a commonly DNA amplified region in ovarian cancer and increase in 20q13 copy number may be an early event, we examined the DNA amplification and RNA expression pattern of 239 microarray probes mapping to this region with the goal of identifying gene(s) associated with ovarian cancer. Using Agilent expression microarray analysis and FISH to tumor tissue arrays, we narrowed the candidates to 19 genes that were consistently overexpressed in a subset of tumors amplified for both ZNF217 and TPD54, although, interestingly the candidates do not include these two amplified genes. Unsupervised clustering of 225 ovarian samples with respect to RNA expression of these 19 genes allowed identification of a 20q‐amplified subset of 51 (23%) tumors and this subset was significantly correlated with poor outcome. Of the 19 candidate genes in this subset, ADRM1 overexpression was the most highly correlated with amplification, was amplified in a higher percentage of tumors than ZNF217 and TPD54, and was significantly upregulated with respect to stage, recurrence and metastasis. In addition, overexpression of ADRM1 correlates significantly with shorter time to recurrence and overall survival. Functional analysis is now warranted to determine whether ADRM1 is a target for early screening and/or therapy for ovarian cancer. © 2008 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1045-2257
eISSN: 1098-2264
DOI: 10.1002/gcc.20592
Titel-ID: cdi_proquest_miscellaneous_69412033
Format
–
Schlagworte
Adenocarcinoma, Clear Cell - genetics
,
Adenocarcinoma, Clear Cell - metabolism
,
Adenocarcinoma, Clear Cell - secondary
,
Adenocarcinoma, Mucinous - genetics
,
Adenocarcinoma, Mucinous - metabolism
,
Adenocarcinoma, Mucinous - secondary
,
Adenocarcinoma, Papillary - genetics
,
Adenocarcinoma, Papillary - metabolism
,
Adenocarcinoma, Papillary - secondary
,
Blotting, Northern
,
Chromosomes, Human, Pair 20 - genetics
,
Cystadenocarcinoma, Serous - genetics
,
Cystadenocarcinoma, Serous - metabolism
,
Cystadenocarcinoma, Serous - secondary
,
DNA, Neoplasm - genetics
,
Female
,
Gene Amplification
,
Gene Dosage
,
Gene Expression Regulation, Neoplastic
,
Humans
,
Immunoenzyme Techniques
,
Membrane Glycoproteins - genetics
,
Membrane Glycoproteins - metabolism
,
Middle Aged
,
Neoplasm Proteins - genetics
,
Neoplasm Proteins - metabolism
,
Neoplasm Recurrence, Local - genetics
,
Neoplasm Staging
,
Ovarian Neoplasms - genetics
,
Ovarian Neoplasms - metabolism
,
Ovarian Neoplasms - pathology
,
Ovary - metabolism
,
Ovary - pathology
,
Prognosis
,
RNA, Neoplasm - genetics
,
Survival Rate
,
Time Factors
,
Tissue Array Analysis
,
Trans-Activators - genetics
,
Trans-Activators - metabolism
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