Details

Autor(en) / Beteiligte

• Chan, Edward D
• Strand, Matthew J
• Iseman, Michael D

Titel

Treatment Outcomes in Extensively Resistant Tuberculosis

Ist Teil von

• The New England journal of medicine, 2008-08, Vol.359 (6), p.657-659

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• The authors retrospectively analyzed 205 cases of multidrug-resistant tuberculosis to determine what percentage met the definition of extensively drug-resistant tuberculosis and compared the treatment outcomes. Odds ratios for treatment success in the group of patients who had multidrug-resistant tuberculosis, as compared with those who had extensively drug-resistant tuberculosis, were 23.4 for the initial outcome and 21.1 for the long-term outcome. To the Editor: Extensively drug-resistant tuberculosis, which is defined as tuberculosis that is resistant to rifampin, isoniazid, a fluoroquinolone, and a second-line injectable agent, poses a major challenge for global health. 1 – 4 There are few published data from studies comparing treatment outcomes for patients with extensively drug-resistant tuberculosis with the outcomes for patients with multidrug-resistant tuberculosis, which is defined as tuberculosis that is resistant to at least isoniazid and rifampin. Among a series of 205 consecutive patients who were referred to our specialty medical center for respiratory diseases and treated between 1984 and 1998 for multidrug-resistant tuberculosis, the overall long-term . . .