Details

Autor(en) / Beteiligte

• Bliden, Kevin P., BS
• DiChiara, Joseph, BS
• Lawal, Lookman, MD
• Singla, Anand, MD
• Antonino, Mark J., BS
• Baker, Brian A., PharmD
• Bailey, William L., PharmD
• Tantry, Udaya S., PhD
• Gurbel, Paul A., MD, FACC

Titel

The Association of Cigarette Smoking With Enhanced Platelet Inhibition by Clopidogrel

Ist Teil von

• Journal of the American College of Cardiology, 2008-08, Vol.52 (7), p.531-533

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2008

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The Association of Cigarette Smoking With Enhanced Platelet Inhibition by Clopidogrel Kevin P. Bliden, Joseph DiChiara, Lookman Lawal, Anand Singla, Mark J. Antonino, Brian A. Baker, William L. Bailey, Udaya S. Tantry, Paul A. Gurbel Cigarette smoking induces CYP1A2 and may enhance the metabolism of clopidogrel. We examined the effect of smoking on platelet function in 104 current smokers (CS) and 155 nonsmokers (NS) undergoing stenting. Current smokers on chronic clopidogrel displayed lower platelet aggregation (PA) and active glycoprotein (GP) IIb/IIIa expression compared with NS (p ≤ 0.0008 for both). Similarly, CS treated with 600 mg of clopidogrel displayed greater inhibition and lower active GP IIb/IIIa expression compared with NS. In a multivariate Cox regression analysis, current smoking was an independent predictor of low platelet aggregation. Clopidogrel therapy in CS is associated with increased platelet inhibition and lower aggregation compared with NS.