American journal of physiology: endocrinology and metabolism, 2008-08, Vol.295 (2), p.E331-E338
2008
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice
- Ist Teil von
- American journal of physiology: endocrinology and metabolism, 2008-08, Vol.295 (2), p.E331-E338
- Ort / Verlag
- United States: American Physiological Society
- Erscheinungsjahr
- 2008
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- 1 Division of Endocrinology, Diabetes and Metabolism; 2 Institute for Diabetes, Obesity and Metabolism; and 3 Neuroscience Graduate Group, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Submitted 6 September 2007 ; accepted in final form 26 May 2008 Resistin has been linked to components of the metabolic syndrome, including obesity, insulin resistance, and hyperlipidemia. We hypothesized that resistin deficiency would reverse hyperlipidemia in genetic obesity. C57Bl/6J mice lacking resistin [resistin knockout (RKO)] had similar body weight and fat as wild-type mice when fed standard rodent chow or a high-fat diet. Nonetheless, hepatic steatosis, serum cholesterol, and very low-density lipoprotein (VLDL) secretion were decreased in diet-induced obese RKO mice. Resistin deficiency exacerbated obesity in ob/ob mice, but hepatic steatosis was drastically attenuated. Moreover, the levels of triglycerides, cholesterol, insulin, and glucose were reduced in ob/ob -RKO mice. The antisteatotic effect of resistin deficiency was related to reductions in the expression of genes involved in hepatic lipogenesis and VLDL export. Together, these results demonstrate a crucial role of resistin in promoting hepatic steatosis and hyperlipidemia in obese mice. adipocytokine; lipoprotein; triglyceride; cholesterol Address for reprint requests and other correspondence: R. Ahima, Univ. of Pennsylvania School of Medicine, Div. of Endocrinology, Diabetes and Metabolism, 415 Curie Blvd., 712A Clinical Research Bldg., Philadelphia, PA 19104 (email: ahima{at}mail.med.upenn.edu )
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0193-1849eISSN: 1522-1555DOI: 10.1152/ajpendo.00577.2007Titel-ID: cdi_proquest_miscellaneous_69375067
- Format
- –
- Schlagworte
- Adiponectin - blood, Animals, Blood Glucose - metabolism, Body Weight - physiology, Cholesterol - blood, Cholesterol - secretion, Cohort Studies, Fatty Liver - genetics, Fatty Liver - metabolism, Genes, Genetics, Hyperlipidemias - genetics, Hyperlipidemias - metabolism, Immunohistochemistry, Insulin - blood, Leptin - deficiency, Leptin - metabolism, Lipoproteins, VLDL - blood, Liver - metabolism, Liver - secretion, Low density lipoprotein, Male, Metabolic syndrome, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Obese, Obesity, Obesity - genetics, Obesity - metabolism, Resistin - deficiency, Resistin - genetics, Resistin - metabolism, Rodents, Triglycerides - blood, Triglycerides - secretion