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Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy
Ist Teil von
American journal of obstetrics and gynecology, 2008-08, Vol.199 (2), p.163.e1-163.e11
Ort / Verlag
Philadelphia, PA: Mosby, Inc
Erscheinungsjahr
2008
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Objective The purpose of this study was to evaluate the contribution of maternal genotype to the concentration of interleukin (IL)-4, −10, and −13 in the cervix during the first trimester in the context of bacterial vaginosis and cigarette smoking. Study Design In this prospective cohort of 116 pregnant women, we examined 72 single nucleotide polymorphisms (SNPs) in 6 genes: IL-4, IL-4 receptor, IL-10, IL-10 receptor α, IL-10 receptor β, and IL-13. Results Among black women, an IL-10 receptor β SNP (rs6517158) demonstrated significant association with IL-10 concentration ( P = .04), adjusted for bacterial vaginosis. Among white women, there were 4 SNPs in IL-10 receptor α with a highly significant association with IL-10 concentration, adjusted for bacterial vaginosis and smoking. Conclusion Our data demonstrate a significant relation between cervical concentrations of IL-10 and SNPs in the IL-10 receptor α and β genes. The contribution of genotype to IL-10 concentration is significant, even in the consideration of bacterial vaginosis and smoking.