Life sciences (1973), 1999-10, Vol.65 (18), p.1901-1904
1999
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- 4-Hydroxynonenal as a second messenger of free radicals and growth modifying factor
- Ist Teil von
- Life sciences (1973), 1999-10, Vol.65 (18), p.1901-1904
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 1999
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- Immunohistochemical analysis of the distribution of the lipid peroxidation product 4-hydroxynonenal (HNE) in the brain of baboons exposed to experimental hemorrhagic traumatic shock or sepsis showed that systemic oxidative stress and the thereby generated HNE affect the blood:brain barrier and the regulation of cerebral blood flow determing secondary brain damage. Similarly, HNE was determined during ischemia in the brain blood vessels of rats exposed to ischemia/reperfusion injury of the brain. After reperfusion, HNE disappeared from the blood vessels but remained in neurones and in glial cells. Since HNE modulates cell proliferation and differentiation (including proto-oncogene expression), it is postulated that HNE might have prominent local and systemic effects that are not only harmful but beneficial, too, determing the outcome of various pathophysiologcial conditions based on oxidative stress.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0024-3205eISSN: 1879-0631DOI: 10.1016/S0024-3205(99)00444-0Titel-ID: cdi_proquest_miscellaneous_69298127
- Format
- –
- Schlagworte
- 4-hydroxynonenal, Aldehydes - immunology, Aldehydes - metabolism, Aldehydes - pharmacology, Animals, Antibodies, Monoclonal, brain, Brain - blood supply, Brain - metabolism, Brain - pathology, c-fos, Cell Division - drug effects, cell growth, Cerebral Hemorrhage - complications, Cerebral Hemorrhage - metabolism, free radicals, Free Radicals - metabolism, HeLa Cells, Humans, Immunohistochemistry, Ischemic Attack, Transient - metabolism, lipid peroxidation, Muscle, Smooth, Vascular - metabolism, Muscle, Smooth, Vascular - pathology, oxidative stress, Papio, Proto-Oncogene Proteins c-fos - metabolism, Rats, Rats, Wistar, reactive oxygen species, Second Messenger Systems - immunology, Second Messenger Systems - physiology, Sepsis - metabolism, Shock - complications, Shock - metabolism, Thymidine - metabolism