Bioorganic & medicinal chemistry letters, 1999-10, Vol.9 (20), p.2983-2988
1999
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Details
- Autor(en) / Beteiligte
- Titel
- New pyrrole derivatives as antimycobacterial agents analogs of BM212
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 1999-10, Vol.9 (20), p.2983-2988
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 1999
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- During the course of our investigations in the field of azole antimicrobial agents, we have identified BM212 a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 2–6 in the hope of increasing the activity. The microbiological data showed intersting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria. New pyrrole derivatives, analogs of BM212, were synthesized and tested against M. tuberculosis and atypical mycobacteria. They showed an intersting activity. [Display omitted]
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/S0960-894X(99)00510-7Titel-ID: cdi_proquest_miscellaneous_69293125
- Format
- –
- Schlagworte
- Antibacterial agents, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antitubercular Agents - chemistry, Antitubercular Agents - pharmacology, Biological and medical sciences, Medical sciences, Microbial Sensitivity Tests, Mycobacterium - drug effects, Pharmacology. Drug treatments, Piperazines - chemistry, Piperazines - pharmacology, Pyrroles - chemistry, Pyrroles - pharmacology