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Anabolic-Androgenic Steroid Administration Causes Hypertrophy of Immobilized and Nonimmobilized Skeletal Muscle in a Sedentary Rabbit Model
Ist Teil von
American journal of sports medicine, 1999-11, Vol.27 (6), p.718-727
Ort / Verlag
Los Angeles, CA: American Orthopaedic Society for Sports Medicine
Erscheinungsjahr
1999
Quelle
MEDLINE
Beschreibungen/Notizen
Although the use of anabolic agents in athletics has generated extensive publicity and controversy, the potential therapeutic
benefits of these drugs have not been fully investigated. This randomized, blinded experimental study investigated whether
short-term administration of an anabolic-androgenic steroid can limit immobilization-induced muscle atrophy in a rabbit model.
We casted one hindlimb each in 48 New Zealand White rabbits and randomly assigned the rabbits to two groups. The treated group
received weekly intramuscular injections of the anabolic-androgenic steroid, nandrolone decanoate (15 mg/kg). Immobilization
significantly decreased muscle weights in both the treated rabbits and controls. Compared with controls, the body weights
of the treated rabbits increased significantly at 2, 4, and 8 weeks. At 4 and 8 weeks, wet weights, dry weights, and contractile
forces were significantly greater in both the casted and noncasted tibialis anterior muscle-tendon units of the treated group.
Dry weights and casted contractile forces of the extensor digitorum longus muscle unit at 4 weeks and all measures at 8 weeks
were greater in the treated rabbits than in controls. These results are contrary to previously accepted views that anabolic-androgenic
steroid use leads to muscle hypertrophy only in conjunction with strength training. This study adds to the growing evidence
that anabolic-androgenic steroids can produce significant skeletal muscle hypertrophy in sedentary populations.