Details

Autor(en) / Beteiligte

• Fatkin, Diane
• MacRae, Calum
• Sasaki, Takeshi
• Wolff, Matthew R
• Porcu, Maurizio
• Frenneaux, Michael
• Atherton, John
• Vidaillet, Humberto J
• Spudich, Serena
• De Girolami, Umberto
• Seidman, Christine E
• Seidman, J.G
• Muntoni, Francesco
• Müehle, Gerry
• Johnson, Wendy
• McDonough, Barbara

Titel

Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease

Ist Teil von

• The New England journal of medicine, 1999-12, Vol.341 (23), p.1715-1724

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1999

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Dilated cardiomyopathy, a myocardial disorder characterized by dilatation of the cardiac chambers and impaired systolic contraction, is a major cause of congestive heart failure worldwide. Despite advances in therapy, mortality due to dilated cardiomyopathy remains high. 1 , 2 Dilated cardiomyopathy can result from coronary artery disease, myocarditis, or systemic diseases but can also result from a primary (idiopathic) disorder of the myocyte's contractile apparatus, cytoskeleton, or both. 3 The cellular and molecular basis of primary dilated cardiomyopathy remains poorly understood. Approximately one third of cases of idiopathic dilated cardiomyopathy are inherited. 4 – 6 Although this disorder can be transmitted as a recessive or . . .