Journal of natural products (Washington, D.C.), 2008-06, Vol.71 (6), p.1000-1004
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Antiproliferative Oleanane Saponins from Meryta denhamii
- Ist Teil von
- Journal of natural products (Washington, D.C.), 2008-06, Vol.71 (6), p.1000-1004
- Ort / Verlag
- Washington, DC: American Chemical Society and American Society of Pharmacognosy
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Eight new oleanane saponins (1−8) together with four know saponins (9−12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.
- Sprache
- Englisch; Russisch
- Identifikatoren
- ISSN: 0163-3864eISSN: 1520-6025DOI: 10.1021/np8000464Titel-ID: cdi_proquest_miscellaneous_69258701
- Format
- –
- Schlagworte
- Animals, anticarcinogenic activity, Antineoplastic Agents, Phytogenic - chemistry, Antineoplastic Agents, Phytogenic - isolation & purification, Antineoplastic Agents, Phytogenic - pharmacology, Araliaceae, Araliaceae - chemistry, Biological and medical sciences, cell proliferation, chemical structure, cultured cells, cytotoxicity, Drug Screening Assays, Antitumor, General pharmacology, Humans, Italy, Medical sciences, medicinal plants, medicinal properties, Meryta denhamii, Mice, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, oleanane, Oleanolic Acid - analogs & derivatives, Oleanolic Acid - chemistry, Oleanolic Acid - isolation & purification, Oleanolic Acid - pharmacology, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, phytochemicals, Plants, Medicinal - chemistry, saponins, Saponins - chemistry, Saponins - isolation & purification, Saponins - pharmacology, spectral analysis, stereochemistry