Details

Autor(en) / Beteiligte

• Soldes, Oliver S.
• Yunger, John G.
• Hirschl, Ronald B.

Titel

Predictors of malignancy in childhood peripheral lymphadenopathy

Ist Teil von

• Journal of pediatric surgery, 1999-10, Vol.34 (10), p.1447-1452

Ort / Verlag

Philadelphia, PA: Elsevier Inc

Erscheinungsjahr

1999

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Purpose: The aim of this study was to identify factors associated with malignant etiologies of childhood peripheral lymphadenopathy and to construct a model that may be used to assess the risk of malignancy. Methods: The medical records of 60 consecutive patients 18 years old or less who underwent peripheral lymph node biopsies were reviewed. Results: Increasing node size, number of sites of adenopathy, and age were associated with an increasing risk of malignancy ( P < .05 for all variables). Graphs useful for risk determination were constructed based on these variables. Additional factors associated with malignancy included the presence of supraclavicular adenopathy ( P < .01), an abnormal chest x-ray ( P < .01), and fixed nodes ( P < .01). Variables that were not statistically different between patients with benign and malignant adenopathy included the duration of adenopathy ( P = .43) the presence of fever ( P = .36), cough ( P = .14) splenomegaly ( P = .93), skin involvement ( P = .39), tenderness ( P = .49) and bilateral adenopathy ( P = .39). Fluctuance was associated with benign adenopathy ( P < .04). Conclusions: The risk of malignancy increased with increasing size and number of sites of adenopathy and age. Other significant predictors of malignancy included supraclavicular location, an abnormal chest x-ray, and fixed nodes. These data may be used to supplement clinical judgment to predict the risk of malignancy.