Details

Autor(en) / Beteiligte

• Coates, Ralph J
• Khoury, Muin J
• Gwinn, Marta

Titel

Five Genetic Variants Associated with Prostate Cancer

Ist Teil von

• The New England journal of medicine, 2008-06, Vol.358 (25), p.2738-2741

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• To the Editor: We agree with Zheng et al. (Feb. 28 issue) 1 that additional research is needed to assess the value of their finding of genetic variants associated with the risk of prostate cancer. Unfortunately, the planned marketing of a test based on this study 2 is premature and may cause more harm than good. Finding a genetic association is only the first step in the continuum of translating research into practice. 3 The results have not been independently confirmed, and adding the genetic test results to age, region, and family history only marginally improved risk prediction (the area under the curve . . .