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Risk of different histological types of postmenopausal breast cancer by type and regimen of menopausal hormone therapy
International journal of cancer, 2008-08, Vol.123 (4), p.933-941
Flesch‐Janys, Dieter
Slanger, Tracy
Mutschelknauss, Elke
Kropp, Silke
Obi, Nadia
Vettorazzi, Eik
Braendle, Wilhelm
Bastert, Gunter
Hentschel, Stefan
Berger, Jürgen
Chang‐Claude, Jenny
2008
Details
Autor(en) / Beteiligte
Flesch‐Janys, Dieter
Slanger, Tracy
Mutschelknauss, Elke
Kropp, Silke
Obi, Nadia
Vettorazzi, Eik
Braendle, Wilhelm
Bastert, Gunter
Hentschel, Stefan
Berger, Jürgen
Chang‐Claude, Jenny
Titel
Risk of different histological types of postmenopausal breast cancer by type and regimen of menopausal hormone therapy
Ist Teil von
International journal of cancer, 2008-08, Vol.123 (4), p.933-941
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2008
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
In a large population‐based case–control study in Germany, including 3,464 breast cancer cases aged 50–74 at diagnosis and 6,657 population based and frequency matched controls, we investigated the effects of menopausal hormone therapy (HT) by type, regimen, timing and progestagenic constituent on postmenopausal breast cancer risk overall and according to histological type. Data were collected by face‐to‐face interviews. Logistic and polytomous logistic regression analysis were used to estimate odds ratios (OR) and 95%‐confidence intervals (95% CI). Risk of invasive breast cancer was significantly elevated in current users (OR, 1.73, 95% CI, 1.55–1.94) and heterogeneous by histological type (p < 0.01), being more than 2‐fold higher for lobular and tubular than for ductal cancer. Risks for current users varied significantly by type and regimen of HT, with ORs per year of use of 1.05 (95% CI, 1.04–1.06) for continuous combined estrogen–progestagen, 1.03 (95% CI, 1.02–1.04) for cyclical EP and 1.01 (95% CI, 1.00–1.03) for estrogen‐only therapy. No statistically significant increase in risk was observed after 5 years of cessation of HT use for any histological type. Analyses of progestagenic content by regimen revealed a significantly higher risk for continuously administered norethisterone‐ or levonorgestrel‐derived progestagens than for continuously administered progesterone‐derived progestagens (OR, 2.27, 95% CI, 1.98–2.62 vs. 1.47, 95% CI, 1.12–1.93, respectively, p = 0.003), which may be explained by dose rather than type of progestagen. These data suggest that the risks associated with menopausal HT differ by type and regimen of HT and histological type of breast cancer and may vary by progestagenic component, depending on the effective dose. © 2008 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.23655
Titel-ID: cdi_proquest_miscellaneous_69236457
Format
–
Schlagworte
Biological and medical sciences
,
breast cancer
,
Breast Neoplasms - epidemiology
,
Breast Neoplasms - pathology
,
Case-Control Studies
,
epidemiology
,
Estrogen Replacement Therapy
,
Female
,
Germany - epidemiology
,
Gynecology. Andrology. Obstetrics
,
histological type
,
hormone therapy
,
Humans
,
Mammary gland diseases
,
Medical sciences
,
Middle Aged
,
Postmenopause
,
progestin
,
Tumors
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