Farmaco (Società chimica italiana : 1989), 1998-12, Vol.53 (12), p.741-746
1998
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives
- Ist Teil von
- Farmaco (Società chimica italiana : 1989), 1998-12, Vol.53 (12), p.741-746
- Ort / Verlag
- Lausanne: Elsevier SAS
- Erscheinungsjahr
- 1998
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Some 4-phenyl-1,8-naphthyridine derivatives with a piperazino group in the 2- and/or 7-position have been synthesized and evaluated for their tuberculostatic activity. The compounds 1, 6, 10, 17b, c and 19i showed a marked activity against Mycobacterium tuberculosis H 37Rv. For this series of compounds, submitted to biological screening, no structure–activity relationship can be deduced.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-827XeISSN: 1879-0569DOI: 10.1016/S0014-827X(98)00094-9Titel-ID: cdi_proquest_miscellaneous_69200713
- Format
- –
- Schlagworte
- 1,8-Naphthyridines, Antibacterial agents, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antitubercular Agents - chemical synthesis, Antitubercular Agents - pharmacology, Biological and medical sciences, Magnetic Resonance Spectroscopy, Medical sciences, Microbial Sensitivity Tests, Mycobacterium tuberculosis - drug effects, Naphthyridines - chemical synthesis, Naphthyridines - pharmacology, Pharmacology. Drug treatments, Piperazino derivatives, Tuberculostatic agents