Details

Autor(en) / Beteiligte

• Achermann, John C.
• Hindmarsh, Peter C.
• D. Brook, Charles G.

Titel

The relationship between the growth hormone and insulin-like growth factor axis in long-term survivors of childhood brain tumours

Ist Teil von

• Clinical endocrinology (Oxford), 1998-11, Vol.49 (5), p.639-645

Ort / Verlag

Oxford BSL: Blackwell Science Ltd

Erscheinungsjahr

1998

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• OBJECTIVE We compared IGF‐1 and IGFBP3 concentrations in a group of adults treated for brain tumours in childhood with those of matched controls, and investigated the relationship between the GH secretory pattern and IGF‐1/IGFBP3 concentrations in the entire group. DESIGN We performed 24 h serum GH profiles using 20 minute sampling and measured corresponding fasting concentrations of IGF‐1 and IGFBP3. PATIENTS Fourteen adult male long‐term survivors of childhood brain tumours were studied. All had received high dose cranial irradiation ( 30Gy; median 12.8 (range 5.8–14.5) years previously). Nine healthy male volunteers acted as controls. MEASUREMENTS IGF‐1 and IGFBP3 concentrations were measured at 06.00 hours. Peak and trough GH activity within the GH profile was analysed by a distribution method which determined the concentration at or below which the serum GH concentration in the profile spent 95% (peak) and 5% (trough) of the total time. RESULTS Serum IGF‐1 levels were significantly lower in the irradiated group (Irradiated: 200 μg/l vs Control: 265 μg/l; P = 0.001) but the difference in serum IGFBP3 (Irradiated: 2.3 mg/l vs Controls: 2.77 mg/l; P = 0.03) was less marked. Peak GH activity was lower in the irradiated subjects (2.59 mU/l vs 9.04 mU/l; P = 0.0004) and correlated strongly with IGF‐1 (r = 0.62; P = 0.002) but less so with IGFBP3 (r = 0.35; P = 0.09). This was strengthened when the range of activity within the profle (peak − trough) was considered. Trough GH activity had a nonsignificant negative correlation with IGF‐1 and IGFBP3 levels. CONCLUSION The difference in serum IGF‐1 concentrations between irradiated subjects and controls was greater than the difference in serum IGFBP3. Peak GH activity and the range of activity within the profile correlated strongly with IGF‐1 concentrations but less so with IGFBP3.