Details

Autor(en) / Beteiligte

• Wilde, Arthur A.M
• Bhuiyan, Zahurul A
• Crotti, Lia
• Facchini, Mario
• De Ferrari, Gaetano M
• Paul, Thomas
• Ferrandi, Chiara
• Koolbergen, Dave R
• Odero, Attilio
• Schwartz, Peter J

Titel

Left Cardiac Sympathetic Denervation for Catecholaminergic Polymorphic Ventricular Tachycardia

Ist Teil von

• The New England journal of medicine, 2008-05, Vol.358 (19), p.2024-2029

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• A surgical procedure for cardiac sympathetic denervation successfully controlled recurrent polymorphic ventricular tachycardia in three patients with a heritable form of catecholaminergic polymorphic ventricular tachycardia. A surgical procedure for cardiac sympathetic denervation successfully controlled recurrent polymorphic ventricular tachycardia in three patients with a heritable form of catecholaminergic polymorphic ventricular tachycardia. Catecholaminergic polymorphic ventricular tachycardia, first recognized in the 1970s, 1 , 2 is a genetic disorder caused by mutations in genes involved in the calcium homeostasis of cardiac cells. After initial observations linked catecholaminergic polymorphic ventricular tachycardia to chromosome 1, 3 two disease-causing genes were identified: the ryanodine receptor 2 gene ( RYR2 ) 4 , 5 and the cardiac calsequestrin 2 gene ( CASQ2 ). 6 , 7 Catecholaminergic polymorphic ventricular tachycardia is characterized by life-threatening ventricular arrhythmias, usually polymorphic ventricular tachycardia or ventricular fibrillation, especially under conditions of increased sympathetic activity, including physical exercise and emotional stress. 8 , 9 It is often manifested at a young . . .