Details

Autor(en) / Beteiligte

• Guo, Wan-jun
• Ma, Xiao-hong
• Wang, Ying-cheng
• Pu, Zhen
• Wei, Geng
• Ji, Yu-lin
• Wang, Zheng
• Yan, Cheng-yin
• Shi, Xiao-ming
• Liu, Xie-he
• Collier, David A
• Ball, David
• Li, Tao

Titel

Functional polymorphism of CYP2E1 gene and alcohol use disorders in a Tibetan population

Ist Teil von

• Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2008-04, Vol.33 (4), p.284-292

Ort / Verlag

China

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To investigate the relationship between the CYP2E1 ＊ c1/ ＊ c2 polymorphism and alcohol use disorders, and the potential influence of the CYP2E1 ＊ c1/ ＊ c2 polymorphism on the severity and dimensions of alcohol use disorders in Tibetan. Methods Three hundred and forty Tibetans with Alcohol Use Disorders Identification Test （AUDIT） score ≥ 10 and another 315 matched control subjects with AUDIT score ≤5 were enrolled. The CYP2E1 ＊ c1/ ＊ c2 polymorphism was determined by the standard PCR-RFLP method. Results The frequency of the CYP2E1 ＊ c2 allele in subjects with alcohol use disorders （16. 2% ） was significantly higher than that of the controls （10.8%）, with a P value of 0.005 and OR value of 1.60 （95% CI： 1.15-2.21）. There was also a significant difference in genotype frequencies between the 2 groups （ χ^2 = 8.75 , P = 0.01 ）. Subjects with alcohol use disorders had higher frequencies of genotypes with at least one copy of allele c2 （28.5% vs. 18.7% ; χ^2 =8.65, P=0.003; OR =1.73） than the control group. The associ- ation of CYP2E1 ＊ c2 allele with alcohol use disorders was much stronger in males than in females, with a male OR value of 2.30. CYP2E1 ＊ c2 allele was associated with increased alcohol consumption and alcohol use disorders in males. Conclusion There is the positive association among CYP2E1 ＊ c2 allele, alcohol use disorders, and the amount of alcohol consumption in Tibetan population.