Details

Autor(en) / Beteiligte

• van Beers, Eduard J
• van Tuijn, Charlotte F.J
• Mac Gillavry, Melvin R
• van der Giessen, Anna
• Schnog, John-John B
• Biemond, Bart J
• on behalf of CURAMA study group

Titel

Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practice

Ist Teil von

• Haematologica (Roma), 2008-05, Vol.93 (5), p.757-760

Ort / Verlag

Pavia: Haematologica

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• 1 Department of Hematology, Academic Medical Center, Amsterdam 2 Department of Cardiology, Slotervaart Hospital, Amsterdam 3 Erasmus Medical Center, Rotterdam, The Netherlands Correspondence: Bart J. Biemond, MD, Department of Haematology, F4-224, Academic Medical Center, PO box 22660, 1100 DD Amsterdam, The Netherlands. E-mail: b.j.biemond{at}amc.uva.nl In daily clinical practice, the frequency of painful crises (pain rate) is an important parameter of sickle cell disease severity. We assessed the prevalence of sickle cell disease-related organ damage and complications and their relation to pain rate. Organ damage and history of vaso-occlusive complications were obtained via systematic screening of consecutive patients and by chart review. In 104 adult sickle cell patients pain rate was related to a history of acute chest syndromes, avascular osteonecrosis, iron overload, priapism and cholelithiasis. However, major disease-related complications, such as microalbuminuria and pulmonary hypertension, were detected in 23% and 24% respectively of patients without painful crises in the study period underlining the importance of systematic screening for developing organ damage in sickle cell patients irrespective of pain rate. Key words: sickle cell disease, organ damage, pain rate, systematic screening.