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BibTeX
Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies
NMR in biomedicine, 2008-05, Vol.21 (4), p.322-336
Torres, Suzana
Prata, Maria I. M.
Santos, Ana C.
André, João P.
Martins, José A.
Helm, Lothar
Tóth, Éva
García-Martín, Maria L.
Rodrigues, Tiago B.
López-Larrubia, Pilar
Cerdán, Sebastián
Geraldes, Carlos F. G. C.
2008
Details
Autor(en) / Beteiligte
Torres, Suzana
Prata, Maria I. M.
Santos, Ana C.
André, João P.
Martins, José A.
Helm, Lothar
Tóth, Éva
García-Martín, Maria L.
Rodrigues, Tiago B.
López-Larrubia, Pilar
Cerdán, Sebastián
Geraldes, Carlos F. G. C.
Titel
Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in vitro characterization and in vivo animal imaging studies
Ist Teil von
NMR in biomedicine, 2008-05, Vol.21 (4), p.322-336
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2008
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The recently reported amphiphilic chelate, [Gd(EPTPAC16)(H2O)]2−, forms supramolecular aggregates in aqueous solution by self‐assembly of the monomers with a relaxometrically determined critical micellar concentration (CMC) of 0.34 mM. The effect of sonication on the aggregate size was characterized by dynamic light scattering and relaxometry, indicating the presence of premicellar aggregates and an overall decrease in aggregate size and polydispersity upon sonication, slightly below the CMC. {[153Sm](EPTPAC16)(H2O)}2− radiotracer was evaluated in vivo from γ scintigraphy and biodistribution in Wistar rats. It was found to depend strongly on the sample concentration, below or above the CMC, and its sonication, in a way that correlates with the effect of the same factors on the size of the aggregates formed in solution. Below CMC, the very large aggregates of the [153Sm]3+‐labeled chelate were persistently and mainly taken up by the lungs, and also by the macrophage‐rich liver and spleen. Sonication of this solution led to loss of the lung uptake. Above CMC, the metal chelate was mainly taken up by the liver, with very little uptake by the spleen and lungs. In vivo, dynamic contrast‐enhanced (DCE)‐MRI evaluation of the micellar [Gd(EPTPAC16)(H2O)]2− compound in Wistar rats showed a persistent hepatic positive‐contrast effect in T1‐weighted images, qualitatively similar to the clinically established GdIII‐based hepatobiliary‐selective agents. No enhancement effect was observed in the lungs because of the scarcity of mobile protons in this organ, despite the scintigraphic evidence of significant lung retention of the [153Sm]3+‐labeled chelate at concentrations below the CMC. Copyright © 2007 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0952-3480
eISSN: 1099-1492
DOI: 10.1002/nbm.1194
Titel-ID: cdi_proquest_miscellaneous_69161565
Format
–
Schlagworte
Animals
,
Chelating Agents - chemistry
,
Chelating Agents - pharmacokinetics
,
Chelating Agents - pharmacology
,
contrast agents
,
Contrast Media - chemistry
,
Contrast Media - pharmacokinetics
,
Contrast Media - pharmacology
,
dynamic light scattering
,
gadolinium
,
Imaging, Three-Dimensional - methods
,
Light
,
Liver - diagnostic imaging
,
Liver - metabolism
,
liver targeting
,
Magnetic Resonance Imaging
,
Male
,
micelles
,
MRI
,
Organ Specificity - drug effects
,
Organometallic Compounds - chemistry
,
Organometallic Compounds - pharmacokinetics
,
Organometallic Compounds - pharmacology
,
Radionuclide Imaging
,
Rats
,
Rats, Wistar
,
Scattering, Radiation
,
self-assembly
,
Solutions
,
Sonication
,
Time Factors
,
Tissue Distribution - drug effects
,
Water
,
γ scintigraphy
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