Details

Autor(en) / Beteiligte

• Bolker, M

Titel

Sex and Crime: Heterotrimeric G Proteins in Fungal Mating and Pathogenesis

Ist Teil von

• Fungal Genetics and Biology, 1998-12, Vol.25 (3), p.143-156

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1998

Quelle

ScienceDirect

Beschreibungen/Notizen

• Heterotrimeric G proteins act as signal transducers that couple cell-surface receptors to cytoplasmic effector proteins. In fungi, G proteins play essential roles during sexual and pathogenic development. They are part of the pheromone signaling cascade in both ascomycetes and basidiomycetes, which is crucial for the recognition and fusion of cells of opposite mating type. In addition, G proteins affect a number of developmental and morphogenetic processes which determine the virulence of plant and human fungal pathogens. Cloning and targeted disruption of genes encoding α subunits of G proteins allowed the attribution of specific functions to these signal transducing molecules. Several lines of evidence indicate that many of the known fungal G proteins influence the intracellular level of cAMP by either stimulating or inhibiting adenylyl cyclase.