Details

Autor(en) / Beteiligte

• Liverton, Nigel J.
• Armstrong, Donna J.
• Claremon, David A.
• Remy, David C.
• Baldvin, John J.
• Lynch, Robert J.
• Zhang, Guixiang
• Gould, Robert J.

Titel

Nonpeptide glycoprotein IIb/IIIa inhibitors: Substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists

Ist Teil von

• Bioorganic & medicinal chemistry letters, 1998-03, Vol.8 (5), p.483-486

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

1998

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics. The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones is described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics.