Details

Autor(en) / Beteiligte

• Gleave, D.Mark
• Brickner, Steven J.
• Manninen, Peter R.
• Allwine, Debra A.
• Lovasz, Kristine D.
• Rohrer, Douglas C.
• Tucker, John A.
• Zurenko, Gary E.
• Ford, Charles W.

Titel

Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones

Ist Teil von

• Bioorganic & medicinal chemistry letters, 1998-05, Vol.8 (10), p.1231-1236

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

1998

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site. A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. These compounds are closely related to the known antibacterial agent DuP 721. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones at the binding site.