Details

Autor(en) / Beteiligte

• Koppelman, Gerard H., MD, PhD

Titel

Gene-environment interaction in allergic disease: More questions, more answers?

Ist Teil von

• Journal of allergy and clinical immunology, 2007-12, Vol.120 (6), p.1266-1268

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• In this study children carrying the promoter CD14/-1721 AA genotype are at decreased risk for asthma and allergic rhinoconjunctivitis compared with carriers of the GG genotype when exposed to farm milk, whereas no difference in disease risk is observed in children not exposed to farm milk. [...]children with the CD14/-1721 AA genotype exposed to farm milk in the first year of life have increased CD14 mRNA expression levels in peripheral blood leukocytes compared with those in children not exposed to farm milk. [...]the article by Bieli et al7 reports an interesting and potentially important interaction of CD14 gene variants and farm milk consumption.