Details

Autor(en) / Beteiligte

• Jung, Tobias
• Bader, Nicolle
• Grune, Tilman

Titel

Lipofuscin: formation, distribution, and metabolic consequences

Ist Teil von

• Annals of the New York Academy of Sciences, 2007-11, Vol.1119 (1), p.97-111

Ort / Verlag

United States

Erscheinungsjahr

2007

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• One of the highlights of postmitotic aging is the intracellular accumulation of highly oxidized and cross-linked proteins, known as lipofuscin. Lipofuscin is insoluble and not degradable by lysosomal enzymes or the proteasomal system, which is responsible for the recognition and degradation of misfolded and oxidatively damaged proteins. These aggregates have been found in various cell types, including heart, liver, kidney, neuronal tissue, and dermal tissue, and are associated with the life span of a single postmitotic cell and, consequently, of the whole organism. Lipofuscin formation appears to depend on the rate of oxidative damage to proteins, the functionality of mitochondrial repair systems, the proteasomal system, and the functionality and effectiveness of the lysosomes. This review highlights the current knowledge of the formation, distribution, and effects of lipofuscin in mammalian cells.