Haematologica (Roma), 2007-12, Vol.92 (12), p.1717-1718
2007
Details
- Autor(en) / Beteiligte
- Titel
- JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis
- Ist Teil von
- Haematologica (Roma), 2007-12, Vol.92 (12), p.1717-1718
- Ort / Verlag
- Pavia: Haematologica
- Erscheinungsjahr
- 2007
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- * Departments of Pathology and ° Clinical Hematology Hospital del Mar, IMAS, Barcelona; # Department of Hematology, Hospital Clínic, University of Barcelona; @ Department of Hematology, Hospital Clínic, Valencia; ^ Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, Spain Correspondence: Carles Besses, MD, PhD, Department of Clinical Hematology, Hospital del Mar, Passeig Marítim 25-29 08003, Barcelona, Spain. Phone: international +34.9.32483341. Fax: international +34.9.32483131. E-mail: 92717{at}imas.imim.es JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage. Initial hematologic data of these patients differ from those of V617F-positive patients, but there is no difference in thrombotic development and myelofibrotic transformation. Key words: JAK2 mutation, exon 12, V617F mutation, PV, erythrocytosis. Related Article Somatic mutations of JAK2 exon 12 as a molecular basis of erythrocytosis Mario Cazzola Haematologica 2007 92: 1585-1589. [Full Text] [PDF]
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0390-6078eISSN: 1592-8721DOI: 10.3324/haematol.12011Titel-ID: cdi_proquest_miscellaneous_69029680
- Format
- –
- Schlagworte
- Adult, Aged, Biological and medical sciences, Diseases of red blood cells, Female, Hematologic and hematopoietic diseases, Humans, Janus Kinase 2 - genetics, Janus Kinase 2 - metabolism, Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis, Medical sciences, Middle Aged, Mutation, Missense, Myeloid Cells - enzymology, Polycythemia - complications, Polycythemia - enzymology, Polycythemia - genetics, Polycythemia Vera - complications, Polycythemia Vera - enzymology, Polycythemia Vera - genetics, Polycythemias, Primary Myelofibrosis - enzymology, Primary Myelofibrosis - etiology, Primary Myelofibrosis - genetics, Thrombosis - enzymology, Thrombosis - etiology, Thrombosis - genetics