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Antimicrobial Effects of Flavone Analogues and Their Structure-Activity Relationships
Ist Teil von
Journal of microbiology and biotechnology, 2007-03, Vol.17 (3), p.530-533
Ort / Verlag
Seoul: Korean Society for Applied Microbiology
Erscheinungsjahr
2007
Quelle
MEDLINE
Beschreibungen/Notizen
It has been well known that the use of Saccharomyces cerevisiae can cause fungemia in critically ill patients and flavone shows an antimicrobial effect on S. cerevisiae. Therefore, we have investigated the activities of thirteen flavone analogues on S. cerevisiae in our studies. Because flavonoids including flavones have antioxidative effects, we try to carry out the activity studies of flavone analogues in vitro and in vivo. In addition, the relationships between the structures of flavone analogues and their biological activities, such as antimicrobial and antioxidative effects, were elucidated using Comparative Molecular Field Analysis calculations.