Details

Autor(en) / Beteiligte

• Young, J.M. (Konkuk University, Seoul, Republic of Korea)
• Park, Y.H. (Konkuk University, Seoul, Republic of Korea)
• Lee, Y.U. (Konkuk University, Seoul, Republic of Korea)
• Kim, H.J. (Konkuk University, Seoul, Republic of Korea)
• Shim, Y.H. (Konkuk University, Seoul, Republic of Korea)
• Ahn, J.H. (Konkuk University, Seoul, Republic of Korea)
• Lim, Y.H. (Konkuk University, Seoul, Republic of Korea), E-mail: yoongho@konkuk.ac.kr

Titel

Antimicrobial Effects of Flavone Analogues and Their Structure-Activity Relationships

Ist Teil von

• Journal of microbiology and biotechnology, 2007-03, Vol.17 (3), p.530-533

Ort / Verlag

Seoul: Korean Society for Applied Microbiology

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• It has been well known that the use of Saccharomyces cerevisiae can cause fungemia in critically ill patients and flavone shows an antimicrobial effect on S. cerevisiae. Therefore, we have investigated the activities of thirteen flavone analogues on S. cerevisiae in our studies. Because flavonoids including flavones have antioxidative effects, we try to carry out the activity studies of flavone analogues in vitro and in vivo. In addition, the relationships between the structures of flavone analogues and their biological activities, such as antimicrobial and antioxidative effects, were elucidated using Comparative Molecular Field Analysis calculations.