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BibTeX
Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects
Journal of magnetic resonance imaging, 2006-11, Vol.24 (5), p.1117-1123
Buckley, David L.
Shurrab, Ala'a E.
Cheung, Ching M.
Jones, Andrew P.
Mamtora, Hari
Kalra, Philip A.
2006
Details
Autor(en) / Beteiligte
Buckley, David L.
Shurrab, Ala'a E.
Cheung, Ching M.
Jones, Andrew P.
Mamtora, Hari
Kalra, Philip A.
Titel
Measurement of single kidney function using dynamic contrast-enhanced MRI: Comparison of two models in human subjects
Ist Teil von
Journal of magnetic resonance imaging, 2006-11, Vol.24 (5), p.1117-1123
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Purpose To compare two methods for assessing the single kidney glomerular filtration rate (SK‐GFR) in humans using dynamic contrast‐enhanced (DCE)‐MRI. Materials and Methods Images were acquired from 39 separate MR studies of patients with atherosclerotic renovascular disease (ARVD). Data from the kidneys and descending aorta were analyzed using both a Rutland‐Patlak plot and a compartmental model. MR estimates of the SK‐GFR were compared with standard radioisotope measures in a total of 75 kidneys. Results Estimates of renal function using both techniques correlated well with radioisotope‐assessed SK‐GFR (Spearman's ρ = 0.81, Rutland‐Patlak; ρ = 0.71, compartmental model). The Rutland‐Patlak approach provided a near one‐to‐one correspondence, while the compartmental method tended to overestimate SK‐GFR. However, the compartmental model fits to the experimental data were significantly better than those obtained using the Rutland‐Patlak approach. Conclusion DCE‐MRI of the kidneys provides data that correlate well with reference measures of SK‐GFR. However, further work, including image registration, is needed to isolate measurement of glomerular filtration to the level of the renal cortex. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1053-1807
eISSN: 1522-2586
DOI: 10.1002/jmri.20699
Titel-ID: cdi_proquest_miscellaneous_69010267
Format
–
Schlagworte
Aged
,
Aged, 80 and over
,
Algorithms
,
Computer Simulation
,
Contrast Media
,
Female
,
gadolinium
,
Gadolinium DTPA - metabolism
,
Gadolinium DTPA - pharmacokinetics
,
glomerular filtration
,
Humans
,
Image Enhancement - methods
,
Image Interpretation, Computer-Assisted - methods
,
kidney
,
Kidney - pathology
,
Kidney - physiopathology
,
Kidney Diseases - diagnosis
,
Kidney Diseases - physiopathology
,
Kidney Function Tests - methods
,
Kinetics
,
Magnetic Resonance Imaging - methods
,
Male
,
Middle Aged
,
Models, Biological
,
perfusion
,
renovascular disease
,
Reproducibility of Results
,
Sensitivity and Specificity
,
tracer kinetics
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