Details

Autor(en) / Beteiligte

• Fearfield, L.A.
• Larkin, J.M.G.
• Rowe, A.
• A'Hern, R.
• Fisher, C.
• Francis, N.
• MacKie, R.
• McCann, B.
• Gore, M.E.
• Bunker, C.B.

Titel

Expression of p16, CD95, CD95L and Helix pomatia agglutinin in relapsing and nonrelapsing very thin melanoma

Ist Teil von

• British journal of dermatology (1951), 2007-03, Vol.156 (3), p.440-447

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Background  The incidence of malignant melanoma is increasing worldwide and patients are being diagnosed earlier with thinner primary lesions. Most patients with very thin melanoma (Breslow thickness < 0·76 mm) are cured by surgery but 2–18% relapse locally or with distant metastases. Objectives  The objective of this study was to establish potential new prognostic markers in very thin melanoma. Methods  We identified a group of subjects with relapsing very thin primary cutaneous melanoma and a matched control group who had not relapsed. We investigated the expression of p16, Helix pomatia agglutinin (HPA), CD95 and CD95 ligand (CD95L) by immunohistochemistry on paraffin‐embedded tissue sections from the subject group, their subsequent metastases and the control group. Results  Reduced p16 expression was significantly associated with relapse in very thin melanoma (P = 0·0129). Loss of p16 expression was also found in 76% of metastases. There was no significant association between HPA, CD95 or CD95L expression and subsequent relapse. Conclusions  This work is the first to show a significant loss of p16 in relapsing very thin melanoma.