Journal of neuroimmunology, 2007-02, Vol.183 (1), p.225-231
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Interferon receptor expression in multiple sclerosis patients
- Ist Teil von
- Journal of neuroimmunology, 2007-02, Vol.183 (1), p.225-231
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNβ treatment response in MS patients. MS patients treated with IFNβ had a significant decrease in IFNAR1 and IFNAR2 expression, and a significant increase in MxA compared to non-treated patients and healthy controls. Also, those patients who had a good response to treatment had a significant decrease in IFNAR1 and IFNAR2 expression compared to non-responders, non-treated patients and healthy controls. IFNβ influences the expression of its receptors, and is greater in patients who respond to IFNβ treatment. This down-regulation could be indicative of the response to IFNβ.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-5728eISSN: 1872-8421DOI: 10.1016/j.jneuroim.2006.11.010Titel-ID: cdi_proquest_miscellaneous_69000655
- Format
- –
- Schlagworte
- Adult, Allergy and Immunology, Female, Gene Expression Regulation - drug effects, Gene Expression Regulation - physiology, Humans, IFNAR, Interferon beta, Interferon-beta - therapeutic use, Male, Middle Aged, Multiple sclerosis, Multiple Sclerosis - drug therapy, Multiple Sclerosis - metabolism, MxA, Neurology, Receptors, Interferon - genetics, Receptors, Interferon - metabolism, Reverse Transcriptase Polymerase Chain Reaction - methods, RNA, Messenger - metabolism