Details

Autor(en) / Beteiligte

• Lang, Gerhard
• Mitova, Maya I
• Cole, Anthony L. J
• Din, Laily B
• Vikineswary, Sabaratnam
• Abdullah, Noorlidah
• Blunt, John W
• Munro, Murray H. G

Titel

Pterulamides I−VI, Linear Peptides from a Malaysian Pterula sp

Ist Teil von

• Journal of natural products (Washington, D.C.), 2006-10, Vol.69 (10), p.1389-1393

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Six new linear peptides, pterulamides I−VI (1−6), were isolated from the fruiting bodies of a Malaysian Pterula species. The structures were elucidated by MS and 2D NMR experiments, and the absolute configurations of the constituent amino acids established using Marfey's method. The pterulamides are mainly assembled from nonpolar N-methylated amino acids and, most interestingly, have non-amino-acid N-terminal groups, among them the unusual cinnamoyl, (E)-3-methylsulfinylpropenoyl, and (E)-3-methylthiopropenoyl groups. Furthermore, pterulamides I−V are the first natural peptides with a methylamide C-terminus. Pterulamides I and IV are cytotoxic against the P388 cell line with IC50 values of 0.55 and 0.95 μg/mL (0.79 and 1.33 μM), respectively.