Nature reviews. Cancer, 2006-11, Vol.6 (11), p.846-856
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Polycomb silencers control cell fate, development and cancer
- Ist Teil von
- Nature reviews. Cancer, 2006-11, Vol.6 (11), p.846-856
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1474-175XeISSN: 1474-1768DOI: 10.1038/nrc1991Titel-ID: cdi_proquest_miscellaneous_68993265
- Format
- –
- Schlagworte
- Animals, Apoptosis, Cancer, Care and treatment, Gene mutations, Gene Silencing, Genetic aspects, Health aspects, Humans, Identification and classification, Neoplasms - genetics, Neoplasms - pathology, Neoplasms - physiopathology, Polycomb-Group Proteins, Prognosis, Repressor Proteins - genetics, Repressor Proteins - physiology, Tumor suppressor genes