Science (American Association for the Advancement of Science), 2006-10, Vol.314 (5798), p.475-478
- Papassotiropoulos, Andreas
- Stephan, Dietrich A
- Huentelman, Matthew J
- Hoerndli, Frederic J
- Craig, David W
- Pearson, John V
- Huynh, Kim-Dung
- Brunner, Fabienne
- Corneveaux, Jason
- Osborne, David
- Wollmer, M. Axel
- Aerni, Amanda
- Coluccia, Daniel
- Hänggi, Jürgen
- Mondadori, Christian R.A
- Buchmann, Andreas
- Reiman, Eric M
- Caselli, Richard J
- Henke, Katharina
- Quervain, Dominique J.-F. de
2006
Details
- Autor(en) / Beteiligte
- Papassotiropoulos, Andreas
- Stephan, Dietrich A
- Huentelman, Matthew J
- Hoerndli, Frederic J
- Craig, David W
- Pearson, John V
- Huynh, Kim-Dung
- Brunner, Fabienne
- Corneveaux, Jason
- Osborne, David
- Wollmer, M. Axel
- Aerni, Amanda
- Coluccia, Daniel
- Hänggi, Jürgen
- Mondadori, Christian R.A
- Buchmann, Andreas
- Reiman, Eric M
- Caselli, Richard J
- Henke, Katharina
- Quervain, Dominique J.-F. de
- Titel
- Common Kibra Alleles Are Associated with Human Memory Performance
- Ist Teil von
- Science (American Association for the Advancement of Science), 2006-10, Vol.314 (5798), p.475-478
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2006
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1129837Titel-ID: cdi_proquest_miscellaneous_68983131
- Format
- –
- Schlagworte
- Adolescent, Adult, Alleles, Animals, Attention, Biological and medical sciences, Brain - physiology, Brain Chemistry, Calcium-Binding Proteins - genetics, Cohort Studies, Coordinate systems, Female, Fundamental and applied biological sciences. Psychology, Gene Expression, Genotype, Genotypes, Haplotypes, Hippocampus, Hippocampus - chemistry, Hippocampus - physiology, Human, Human genetics, Humans, Intracellular Signaling Peptides and Proteins, Learning. Memory, Magnetic Resonance Imaging, Male, Membrane Proteins - genetics, Memory, Memory recall, Mice, Middle Aged, Phosphoproteins, Polymorphism, Single Nucleotide, Population genetics, Proteins - analysis, Proteins - genetics, Proteins - physiology, Psychology. Psychoanalysis. Psychiatry, Psychology. Psychophysiology, Reverse Transcriptase Polymerase Chain Reaction, Switzerland, Temporal lobe, United States