Details

Autor(en) / Beteiligte

• Lima, Luciana Moreira
• Carvalho, Maria das Graças
• Loures-Vale, Andréia Assis
• Fernandes, Ana Paula
• Mota, Ana Paula Lucas
• Neto, Cirilo Pereira da Fonseca
• Garcia, José Carlos Faria
• Saad, Jamil Abdala
• Souza, Marinez de Oliveira

Titel

Increased serum levels of lipoprotein(a) correlated with the severity of coronary artery disease in patients submitted to angiography

Ist Teil von

• Arquivos brasileiros de cardiologia, 2006-09, Vol.87 (3), p.260-266

Ort / Verlag

Brazil

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine serum levels of lipoprotein(a) and lipid profile of a group of individuals submitted to coronary angiography, with the aim of establishing the possible correlation between these parameters and the severity of coronary artery disease. Serum levels of total cholesterol, HDLC, LDLC, triglycerides, lipoprotein(a), apolipoproteins A-I and B were measured in blood samples of 17 subjects with absence of atheromatosis in the coronary arteries (control), 12 subjects presenting mild/moderate atheromatosis and 28 subjects presenting severe atheromatosis. No significant statistical differences were found between the means of the three groups for the parameters assessed, except for lipoprotein(a) serum levels which presented significant differences between the means of the control, mild/moderate atheromatosis and severe atheromatosis groups (p<0.001). The means obtained in the three groups for Lp(a) indicate a progressive increase in the serum levels of this parameter according to the severity of coronary atheromatosis. These findings suggest the need of additional studies in order to obtain enough evidence to support the introduction of routine assessment of Lp(a) levels in clinical laboratories in the monitoring of patients at risk for coronary artery disease (CAD).