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Risk of Colorectal Cancer Is Linked to Erythrocyte Compositions of Fatty Acids as Biomarkers for Dietary Intakes of Fish, Fat, and Fatty Acids
Ist Teil von
Cancer epidemiology, biomarkers & prevention, 2006-10, Vol.15 (10), p.1791-1798
Ort / Verlag
Philadelphia, PA: American Association for Cancer Research
Erscheinungsjahr
2006
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Consumption of fish rich in n-3 polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid, is suggested to reduce
colorectal cancer risk through inhibition of the arachidonic acid (AA) cascade related to tumorigenesis and cell proliferation.
High intake of saturated fatty acids (SFAs) may increase the risk. To examine associations between colorectal cancer risk
and fatty acid compositions in erythrocyte membranes, as biomarkers for dietary intakes of fish, fat, and fatty acids, we
conducted a case-control study with 74 incident cases and 221 noncancer controls (matched by age, sex, and season of sample
collection). Erythrocyte fatty acids were measured using an accelerated solvent extraction and a gas-liquid chromatography.
Colorectal cancer had no association with dietary intakes of meat, fish, fat, and fatty acids. However, the risk was inversely
associated with erythrocyte compositions of docosahexaenoic acid, AA, and PUFAs [the highest to the lowest tertile, odds ratios,
0.36, 0.42, and 0.15; 95% confidence intervals, 0.14-0.93, 0.18-0.95, and 0.05-0.46; P trend < 0.05, respectively] and positively with those of palmitic acid, SFAs, and the ratio of SFAs/PUFAs (odds ratios, 6.46, 8.20,
and 9.45; 95% confidence intervals, 2.41-17.26, 2.86-23.52, and 2.84-31.43; P trend < 0.005, respectively). In conclusion, we could clearly show decreased and increased risks for colorectal cancer related
to PUFAs and SFAs compositions in erythrocyte membranes, respectively, but further research is needed to investigate the discrepancy
between our findings and the generally accepted role of the AA cascade. (Cancer Epidemiol Biomarkers Prev 2006;15(10):1791–8)