Details

Autor(en) / Beteiligte

• Zeng, Y

Titel

Principles of micro-RNA production and maturation

Ist Teil von

• Oncogene, 2006-10, Vol.25 (46), p.6156-6162

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2006

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Micro-RNAs (miRNAs) are a class of approximately 22-nucleotide non-coding RNAs expressed in multicellular organisms. They are first transcribed in a similar manner to pre-mRNAs. The transcripts then go through a series of processing steps, including endonucleolytic cleavage, nuclear export and a strand selection procedure, to yield the single-stranded mature miRNA products. The transcription and processing of miRNAs determines the abundance and the sequence of mature miRNAs and has important implications for the function of miRNAs.