Details

Autor(en) / Beteiligte

• Kamboj, Mini
• Weinstock, David
• Sepkowitz, Kent A.

Titel

Progression of Pneumocystis jiroveci Pneumonia in Patients Receiving Echinocandin Therapy

Ist Teil von

• Clinical infectious diseases, 2006-11, Vol.43 (9), p.e92-e94

Ort / Verlag

United States: The University of Chicago Press

Erscheinungsjahr

2006

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Echinocandins are a novel class of antifungal drugs that target β (1, 3)-D-glucan synthesis. Animal studies have shown that these agents have activity against Pneumocystis jiroveci infection; however, clinical data are lacking. We reviewed all cases of proven P. jiroveci pneumonia (PCP) in non–human immunodeficiency virus-infected patients at our hospital over a 5 year period (2001–2005). Two patients received conventional PCP treatment and concomitant use of echinocandins for presumed invasive aspergillus. In both cases, PCP progressed, and the patient died. The use of echinocandins in the prevention or treatment of PCP cannot be recommended without evidence to support their effectiveness.